The official title of the project was: A Phase II, Open Label, Randomized Controlled Trial to Assess the Safety and Efficacy of Convalescent Plasma to Limit COVID-19 Associated Complications
Project Details
Funding
Indian Council of Medical Research
April 2020 to September 2020
₹ 25,000,000 (~US$ 350,000)
Project Brief
The PLACID trial was launched at the height of the COVID-19 pandemic to explore whether convalescent plasma collected from recovered patients could help improve outcomes for those battling moderate-to-severe COVID-19. As one of the earliest and largest multicenter studies on plasma therapy, it brought together clinicians, researchers, and policymakers to generate rapid, high-quality evidence at a time of intense global uncertainty. The findings played an important role in shaping national treatment guidelines and helped clarify the limits and potential of convalescent plasma as a therapeutic option for COVID-19.
Role & Responsbilities
In my capacity as a Co-Investigator, my responsibilities included the development of the trial protocol, the design of the trial, and planning the analysis of the ensuing data. Following the commencement of the study, my role transitioned to providing support to the data management and analysis teams. This study contributed to the ongoing efforts to identify effective treatments for COVID-19 and had major implications for the broader understanding of convalescent plasma therapy in the management of moderarte-to-severe COVID-19 disease and associated complications.
Peer-Reviewed Publications
- Agarwal A, Mukherjee A, Kumar G, Chatterjee P, Bhatnagar T, Malhotra P on behalf of PLACID Trial Investigators. Convalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial). British Medical Journal. 2020 Oct 22;371.
- Mammen JJ, Kumar S, Thomas L, Kumar G, Zachariah A, Jeyaseelan L, Peter JV, Agarwal A, Mukherjee A, Chatterjee P, Bhatnagar T. Factors associated with mortality among moderate and severe patients with COVID-19 in India: a secondary analysis of a randomised controlled trial. BMJ Open. 2021 Oct 1;11(10):e050571.
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