Publication: Time for person centered research in neuroscience: users driving the change

An editorial on the need to have person-centered research agenda, published in the Annals of Neuroscience.

Price A, Chatterjee P, Biswas R. time for person centered research in neuroscience: users driving the change. Annals of Neuroscience. 2014 Apr;21(2):37-40. doi: 10.5214/ans.0972.7531.210201. PubMed PMID: 25206057; PubMed Central PMCID: PMC4117163.

There is an exciting opportunity to change the landscape of clinical trials and new interventions. Research can now be tailored to the needs of the public through the use of public led online trials (PLOTs) and participatory research interventions in the form of user driven healthcare. We explore some of the advantages and pitfalls of collaborative participant centered research. Collaboration is made possible through online communication, social media, and the desire of researchers, the public and clinicians to work collaboratively for the common good.

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Publication: Understanding the basic statistical questions that disturb a medical researcher

A review article which was specially written for the series on “RESEARCH METHODOLOGY: STATISTICS IN MEDICAL RESEARCH” in Astrocyte.

Khan AM, Kumar R, Chatterjee P. Understanding the basic statistical questions that disturb a medical researcher. Astrocyte 2014;1(1):62-6

Abstract

Medical research does not deal with only medical sciences; it is also dependent on other disciplines, and statistics is an integral part in its conduct. It is challenging for a medical researcher to grasp the importance of statistics and also to decide the types of statistical issues in the various phases of his/her medical research. There are inherent variations within and between the human/animal subjects used in medical research and these uncertainties can only be grasped using statistical tools. Initiating a medical research while taking into account the statistical aspects right at the planning stage is one of the best ways to conduct better evidence-based research. The validity of the results of a medical research depends not only on the methodology of conducting the study but also on the analysis of data collected. As opposed to the general perception, statistics not only deals with analysis of data but is also intricately interwoven with the methodology section of the research where sample sizes, inclusion/exclusion criteria, and others are mentioned. Although statistical softwares simplify the computational aspect of statistics, the confusing conceptual aspects make interpretation of the outputs difficult and incorrect. Seemingly simple terms such as population, sample, parameters, and variables have been explained keeping the medical researchers’ perspective in mind. This first article in the series “Statistics in Medical Research” makes an attempt to facilitate the medical researcher to overcome the initial questions that challenge him/her with regard to statistics.

Publication: Daniel Alcides Carrion (1857-1885) and a history of medical martyrdom.

This article focusing on the History of Medicine was published in the Journal of Medical Biography.

Chatterjee P, Chandra S, Biswas T. Daniel Alcides Carrion (1857-1885) and a history of medical martyrdom. J Med Biogr. 2015 Nov;23(4):224-7. doi: 10.1177/0967772013479532. Epub 2014 Jan 27. PubMed PMID: 24585618.

Abstract

Daniel Carrion, a sixth-year medical student, died while investigating the effects of self-inoculation of the causative organism of Oroya Fever and Bartonellosis and thereby contributed to understanding of the disease before the organisms had been identified.

KEYWORDS:

Albero Barton; Autoexperimentation; Bartonella bacilliformis; Bartonellosis; Carman Peredes; Daniel Alcides Carrion; Dos de May Hospital; Dr Richard Strong; Lima; Oroya Fever; Verruga Peruana

Publication: From the editors of a Student journal

This was a special article published as a “Student Contribution” in the journal Education for Health.

Thawani R, Kaur G, Chatterjee P, Biswas T. From the editors of a Student journal. Education for Health 2013;26:115-6.

Abstract

Formal training in research is lacking most of the medical training programs of the world. Research can be of great help in producing more physician scientists. Students’ journals can encourage research amongst medical students. But student journals face a lot of problems. The editors are students who are busy with their curricula. Moreover, there is no compensation. Additionally, since, not many student journals are visible, students doing research try and submit to prestigious journals and when face rejection, get de-motivated. There is no single solution to all the problems faced by a student journal. However, it needs to be appreciated that they are a necessity, hence, they should be encouraged actively. Collaboration between the multiple stakeholders involved (funding agencies, institutions, experts on biomedical ethics, student researchers and their faculty mentors) is the need of the hour to further expand and empower the existing student journals and set up new ones.

Medical education, medical research, student journal

Publication: Governments are legally obliged to ensure adequate access to health information

This article was inspired by the work being done by the Health Information for All by 2015 group in bringing information to both care seekers and care givers.

Bhaumik S, Pakenham-Walsh N, Chatterjee P, Biswas T. Governments are legally obliged to ensure adequate access to health information. Lancet Glob Health. 2013 Sep;1(3):e129-30. doi: 10.1016/S2214-109X(13)70043-3. Epub 2013 Aug 2. PubMed PMID: 25104255.

Abstract

Access to reliable, relevant, and implementable health-care information has been identified as one of the key determinants for reaching the Millennium Development Goals (MDGs).1 In 2006, Pang and coworkers2 noted that the challenge is to “ensure that everyone in the world can have access to clean, clear knowledge—a basic human right, and a public health need as important as access to clean, clear water, and much more easily achievable.” However, this challenge has repeatedly been put on the sidelines.

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Publication: Open Access: The Changing Face of Scientific Publishing

An opinion piece in the Journal of Family Medicine and Primary Care about open access scholarly publishing.

Chatterjee P, Biswas T, Mishra V. Open Access: The changing face of scientific publishing. Journal of Family Medicine and Primary Care 2013;2:128-30

Abstract

The debate on open access to scientific literature that has been raging in scholarly circles for quite some time now has been fueled further by the recent developments in the realm of the open access movement. This article is a short commentary on the current scenario, challenges, and the future of the open access movement.

Keywords: Access to information, free access, information dissemination, open access, publication, publishing

Publication: Association of Sleep Disorders with Essential Hypertension in Subcontinental Population

A small study looking at the association between self-reported sleep disorder and occurrence of undiagnosed hypertension. One of my first research projects.

Sen P, Mukhopadhyay AK, Chatterjee P, Biswas T. Association of sleep disorders with essential hypertension in subcontinental population. Indian Medical Gazette December 2012;146(12):463-6.

Abstract
Effects of sleep disorders on different physiological functions have been studied in depth. One such association is that of insomnia and obstructive sleep apnea with hypertension.

This study intended to evaluate the relationship between sleep disorders and essential hypertension.

In this institution based case-control study, the study population was selected by simple random sampling among all patients attending the outpatient department of Medicine. Patients with major risk factors for essential hypertension and other causes of secondary hypertension were excluded. Patient’s meeting the eligible criteria of blood pressure equal to or greater than 140/90 (mean of 3 readings) mm of Hg were included as cases and matched controls were selected from the rest. The eligible population of 216 people (92 cases, 124 controls) was assessed using the modified SLEEP-50 questionnaire and evaluated using an original “Sleep Scale”.

Significant sleep disorder (Sleep Scale score >6), had a prevalence of 13.89%. The mean sleep scores were significantly higher (p = 0.0037) in cases than controls. The association between sleep disorder and essential hypertension was significant. (Odd’s Ratio=2.270, 95% Confidence Interval 0.970-5.364, p=0.047).

Sleep disorders are an unconventional risk factor for essential hypertension. Further studies are needed to validate
the present observations.

Keywords
essential hypertension, sleep disorder