- The SaniPath-Typhoid explores the dimension of environmental transmission of typhoid and paratyphoid in highly endemic, urban slum settings of Kolkata.
- The study has an innovative laboratory component and a mixed-methods approach to risk exposure quantification. The laboratory component aims to optimize and validate laboratory protocols for the detection of S. Typhi and S. Paratyphi A in various environmental samples; and to optimize and validate protocols for microbial source tracking (MST) to determine the sources of fecal contamination in environmental samples.
- The study aims to assess neighborhood-level environmental risks of exposure to S. Typhi and S. Paratyphi A through behavioral and microbiological data collected using the SaniPath Exposure Assessment Tool and eventually develop and deploy an environmental surveillance strategy to complement clinical surveillance of typhoid and paratyphoid fever
||Dr. Shanta Dutta, Scientist G and Director, ICMR-National Institute of Cholera and Enteric Diseases
- Adapt the generic SaniPath-Typhoid protocol for implementation in India
- Design the sociobehavioral study component
- Project management, ensuring collection of appropriate environmental samples (including animal samples) for lab standardization
- Design the environmental surveillance system protocol based on existing data from clinical surveillance
- Manage regulatory issues for international compliance, including HMSC (Health Ministry Screening Committee) clearance in India and SAM (System for Awards and Management) registration in USA.
- Develop an exchange program for training students and scientists with Emory University
||May 2018 – November 2020 (tentative)
||Emory University, Atlanta, USA, which received funding support from the Bill and Melinda Gates Foundation (BMGF). ₹ 2.8 crore (~US$ 400,000).