SaniPath-Typhoid India

SaniPath Typhoid study on assessment of exposure to typhoid fever in urban slums in India (SaniPath)

Project Brief
  • The SaniPath-Typhoid explores the dimension of environmental transmission of typhoid and paratyphoid in highly endemic, urban slum settings of Kolkata.
  • The study has an innovative laboratory component and a mixed-methods approach to risk exposure quantification. The laboratory component aims to optimize and validate laboratory protocols for the detection of S. Typhi and S. Paratyphi A in various environmental samples; and to optimize and validate protocols for microbial source tracking (MST) to determine the sources of fecal contamination in environmental samples.
  • The study aims to assess neighborhood-level environmental risks of exposure to S. Typhi and S. Paratyphi A through behavioral and microbiological data collected using the SaniPath Exposure Assessment Tool and eventually develop and deploy an environmental surveillance strategy to complement clinical surveillance of typhoid and paratyphoid fever
Principal Investigator Dr. Shanta Dutta, Scientist G and Director, ICMR-National Institute of Cholera and Enteric Diseases
My Role Co-Investigator

  • Adapt the generic SaniPath-Typhoid protocol for implementation in India
  • Design the sociobehavioral study component
  • Project management, ensuring collection of appropriate environmental samples (including animal samples) for lab standardization
  • Design the environmental surveillance system protocol based on existing data from clinical surveillance
  • Manage regulatory issues for international compliance, including HMSC (Health Ministry Screening Committee) clearance in India and SAM (System for Awards and Management) registration in USA.
  • Develop an exchange program for training students and scientists with Emory University
Project Period May 2018 – November 2020 (tentative)
Funding Details Emory University, Atlanta, USA, which received funding support from the Bill and Melinda Gates Foundation (BMGF). ₹ 2.8 crore (~US$ 400,000).
More information